| Id: | acc3440 |
| Group: | 2sens |
| Protein: | NF-kappaB p65 |
| Gene Symbol: | Rela |
| Protein Id: | Q96RU7 |
| Protein Name: | TRIB3_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser536 |
| Site Sequence: | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| Disease Category: | Urinary and reproductive system diseases |
| Disease: | Nephropathy |
| Disease Subtype: | Male Sprague‐Dawley rat |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | cisplatin |
| Drug Info: | Cisplatin is a widely used chemotherapy drug that is effective in treating various types of cancers. |
| Effect: | suppress |
| Effect Info: | "Cisplatin can increase the phosphorylation level of NF-κB in the kidneys, while the MDM2 inhibitor DS–5272 can significantly inhibit this process, indicating its potential to improve cisplatin-induced nephrotoxicity." |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 30564368 |
| Sentence Index: | 30564368_9-10 |
| Sentence: | "Western blotting showed that cisplatin increased NFkappaB phosphorylation in kidneys, which was significantly suppressed by DS-5272. In vitro, we treated HEK 293 cells with cisplatin, in the absence or presence of DS-5272, and examined cytotoxicity and NFkappaB transcriptional activity." |
Sequence & Structure:
MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATAVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG
No data.
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
