PMADS

Id:	acc3450
Group:	2sens
Protein:	JNK
Gene Symbol:	Mapk8
Protein Id:	Q91Y86
Protein Name:	MK08_MOUSE
PTM:	phosphorylation
Site:	Thr183
Site Sequence:	RTAGTSFMMTPYVVTRYYRAP
Disease Category:	Musculoskeletal system diseases
Disease:	Osteoclastogenesis
Disease Subtype:
Disease Cellline:	RAW264.7
Disease Info:
Drug:	ZOL
Drug Info:	ZOL is a drug. Its specific properties and applications may vary depending on context.
Effect:	modulate
Effect Info:	ZOL inhibits osteoclastogenesis and activity by suppressing the phosphorylation (PTM) of JNK.
Note:
Score:	4.0
Pubmed(PMID):	31173157
Sentence Index:	31173157_6-7
Sentence:	"By using a cell viability assay, as well as in vitro osteoclastogenesis, immunofluorescence and resorption pit assays, we demonstrated that ZOL (0.1-5 microM) suppressed receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation and bone resorptive activity. Furthermore, western blot analysis and reverse transcription-quantitative PCR indicated that ZOL inhibited the RANKL-induced activation of NF-kappaB and the phosphorylation of JNK in RAW264.7 cells, and subsequently decreased the expression of osteoclastogenesis-associated genes, including calcitonin receptor, tartrate-resistant acid phosphatase and dendritic cell-specific transmembrane protein."

Sequence & Structure:

MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb