| Id: | acc3470 |
| Group: | 2sens |
| Protein: | CREB |
| Gene Symbol: | Creb1 |
| Protein Id: | Q01147 |
| Protein Name: | CREB1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser133 |
| Site Sequence: | LNDLSSDAPGVPRIEEEKSEE |
| Disease Category: | Nervous system diseases |
| Disease: | Alzheimer's Disease |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Maslinic acid |
| Drug Info: | "Maslinic acid is a natural triterpenoid compound with potential anti - inflammatory, antioxidant and anti - cancer properties." |
| Effect: | modulate |
| Effect Info: | "Administration of ursolic acid can increase the phosphorylation levels of ERK-CREB, PI3K, and PKB (Akt), and improve memory impairment." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32133639 |
| Sentence Index: | 32133639_2-3 |
| Sentence: | "Current AD therapeutic agents have several gastrointestinal or psychological adverse effects and therefore, novel therapeutic agents with fewer adverse effects must be developed. Previously, we demonstrated that oleanolic acid, which is similar in chemical structure to maslinic acid, ameliorates cognitive impairment through the activation of tropomyosin receptor kinase (TrkB)-ERK-cAMP response element-binding protein (CREB) phosphorylation and increased levels of brain-derived neurotrophic factor (BDNF)." |
Sequence & Structure:
MTMESGADNQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 133 | D | Type 2 diabetes | Phosphorylation | 34193609 |
| S | 133 | N | Heart failure | Phosphorylation | 17616745 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
