| Id: | acc3477 |
| Group: | 2sens |
| Protein: | STAT6 |
| Gene Symbol: | Stat6 |
| Protein Id: | P52633 |
| Protein Name: | STAT6_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr641 |
| Site Sequence: | EQMGKDGRGYVSTTIKMTVER |
| Disease Category: | Immune system diseases |
| Disease: | Atopic Dermatitis |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Piperine |
| Drug Info: | "Piperine is an alkaloid found in black pepper and long pepper, which may have various biological activities such as enhancing nutrient absorption." |
| Effect: | modulate |
| Effect Info: | "Piperine treatment can inhibit TMA-induced STAT6 phosphorylation, thereby suppressing Th2-related IL-4 expression and GATA3 activity and improving AD-like lesions." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32392825 |
| Sentence Index: | 32392825_5-6 |
| Sentence: | "Furthermore, piperine inhibited pro-inflammatory cytokines such as TNF-alpha and IL-1beta in mouse ears, compared with the TMA-induced AD group. In measuring allergic immune responses in draining lymph nodes (dLNs), we found that IL-4 secretion, GATA3 mRNA level, and STAT6 phosphorylation were suppressed by piperine treatment." |
Sequence & Structure:
MSLWGLISKMSPEKLQRLYVDFPQRLRHLLADWLESQPWEFLVGSDAFCYNMASALLSATVQRLQATAGEQGKGNSILPHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFRHLPGPFHRKQEELKFTTALGRLQHRVRETRLLRESLQQGAKTGQVSLQNLIDPPVNGPGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPMVRADMVTEKQARELSLAQGPGTGVESTGEIMNNTVPLENSIPSNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFTLGPNKLLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSVEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVPPYDLGMAPDASMQLSSDMGYPPQSIHSFQSLEESMSVLPSFQEPHLQMPPNMSQITMPFDQPHPQGLLQCQSQEHAVSSPEPMLCSDVTMVEDSCLTQPVGGFPQGTWVSEDMYPPLMPPTEQDLTKLLLENQGEAGGSLGSQPLLQPSPYGQSGISLSHLDLRTNPSW
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
