| Id: | acc3495 |
| Group: | 2sens |
| Protein: | IRF3 |
| Gene Symbol: | Irf3 |
| Protein Id: | P70671 |
| Protein Name: | IRF3_MOUSE |
| PTM: | Phosphorylation |
| Site: | Ser396 |
| Site Sequence: | ISNSQPISLTSDQYKAYLQDL |
| Disease Category: | Infectious diseases |
| Disease: | VSV infection |
| Disease Subtype: | |
| Disease Cellline: | mouse peritoneal macrophages |
| Disease Info: | |
| Drug: | Cirsitakaoside |
| Drug Info: | "Cirsitakaoside is a specific drug, but detailed information about its functions and characteristics is not provided here." |
| Effect: | modulate |
| Effect Info: | "Cirsitakaoside activates the RIG - I signaling pathway by promoting the phosphorylation of TBK1 and IRF3, enhancing the production of type I interferons. Meanwhile, it blocks the NF - κB pathway by inhibiting the phosphorylation of p65 and IκBα, reducing the release of pro - inflammatory cytokines, thereby exerting dual antiviral and anti - inflammatory effects. " |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 32652505 |
| Sentence Index: | 32652505_8-9 |
| Sentence: | "Furthermore, Cirsitakaoside significantly increased the VSV-triggered phosphorylation of TBK1, IRF3 and reduced the phosphorylation of IkappaBalpha and p65 in mouse peritoneal macrophages. in vivo, the results showed that Cirsitakaoside-treated mice were more resistant to VSV infection by producing more IFN-beta and less pro-inflammatory cytokines." |
Sequence & Structure:
METPKPRILPWLVSQLDLGQLEGVAWLDESRTRFRIPWKHGLRQDAQMADFGIFQAWAEASGAYTPGKDKPDVSTWKRNFRSALNRKEVLRLAADNSKDPYDPHKVYEFVTPGARDFVHLGASPDTNGKSSLPHSQENLPKLFDGLILGPLKDEGSSDLAIVSDPSQQLPSPNVNNFLNPAPQENPLKQLLAEEQWEFEVTAFYRGRQVFQQTLFCPGGLRLVGSTADMTLPWQPVTLPDPEGFLTDKLVKEYVGQVLKGLGNGLALWQAGQCLWAQRLGHSHAFWALGEELLPDSGRGPDGEVHKDKDGAVFDLRPFVADLIAFMEGSGHSPRYTLWFCMGEMWPQDQPWVKRLVMVKVVPTCLKELLEMAREGGASSLKTVDLHISNSQPISLTSDQYKAYLQDLVEDMDFQATGNI
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 396 | U | Experimental autoimmune encephalomyelitis | Phosphorylation | 33710283 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
