| Id: | acc3516 |
| Group: | 2sens |
| Protein: | AMPK |
| Gene Symbol: | Prkaa1 |
| Protein Id: | P54645 |
| Protein Name: | AAPK1_RAT |
| PTM: | phosphorylation |
| Site: | Thr183 |
| Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
| Disease Category: | Digestive system diseases |
| Disease: | Colitis |
| Disease Subtype: | ulcerative colitis |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Xian-He-Cao-Chang-Yan formula |
| Drug Info: | "Xian-He-Cao-Chang-Yan formula is a drug, likely a traditional Chinese medicine formula used for certain health conditions, but specific efficacy and indications need further research." |
| Effect: | modulate |
| Effect Info: | "Xianhecaochangyanfang enhances the phosphorylation of AMPK both in vivo and in vitro, thereby inhibiting the polarization of M1 macrophages and improving DSS-induced colitis in mice." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 33164773 |
| Sentence Index: | 33164773_10-11 |
| Sentence: | "More importantly, XHCF significantly decreased M1 macrophage markers (CD11c, IL-6 and IL-1beta) whereas increased M2 macrophage markers (CD206) in colitis mice, suggesting it could regulate macrophage polarization. Furthermore, the levels of HK2 and lactic acid in colon tissues were significantly reduced by XHCF, indicating that XHCF could inhibit glycolysis." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSEVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
