| Id: | acc3541 |
| Group: | 2sens |
| Protein: | IRE1 |
| Gene Symbol: | ERN1 |
| Protein Id: | O75460 |
| Protein Name: | ERN1_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser724 |
| Site Sequence: | CKKLAVGRHSFSRRSGVPGTE |
| Disease Category: | Cancer |
| Disease: | Glioma |
| Disease Subtype: | |
| Disease Cellline: | H4 |
| Disease Info: | |
| Drug: | gefitinib |
| Drug Info: | "Gefitinib is an oral, selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in the treatment of certain types of non - small cell lung cancer." |
| Effect: | modulate |
| Effect Info: | "Gefitinib induces glioma cell death by promoting the phosphorylation of IRE1, apoptosis signal-regulating kinase-1 (Ask1), and c-Jun N-terminal kinase (JNK)." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 33920356 |
| Sentence Index: | 33920356_6-7 |
| Sentence: | "Three branches of ER stress, namely Activating Transcription Factor-6 (ATF6), Protein Kinase R (PKR)-Like ER Kinase (PERK), and Inositol-Requiring Enzyme 1 (IRE1), were activated by gefitinib, along with the elevation of intracellular free Ca2+, Reactive Oxygen Species (ROS), and NADPH Oxidase2/4 (NOX2/4). Specifically, elevated IRE1 phosphorylation, Tumor Necrosis Factor (TNF) Receptor-Associated Factor-2 (TRAF2) expression, Apoptosis Signal-Regulating Kinase-1 (Ask1) phosphorylation, c-Jun N-Terminal Kinase (JNK) phosphorylation, and Noxa expression appeared in gefitinib-treated glioma cells." |
Sequence & Structure:
MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDVKFDPGLKSKNKLNYLRNYWLLIGHHETPLSASTKMLERFPNNLPKHRENVIPADSEKKSFEEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDDGDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHEPPEPQPPVTPDAL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| ERN1-Ser533 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.58 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.06 |
| LUAD | -0.115 |
| LUSC | 1.093 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.542 |
| ERN1-Ser536 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | -0.831 |
| LUSC | 1.11 |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.279 |
| ERN1-Ser729 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.707 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
