| Id: | acc3544 |
| Group: | 2sens |
| Protein: | STAT1 |
| Gene Symbol: | Stat1 |
| Protein Id: | P42225 |
| Protein Name: | STAT1_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr701 |
| Site Sequence: | ELDDPKRTGYIKTELISVSEV |
| Disease Category: | Immune system diseases |
| Disease: | Arthritis? |
| Disease Subtype: | Collagen-Induced |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Kurarinone? |
| Drug Info: | Kurarinone is a natural compound that may have various pharmacological activities and is potentially useful in medical research. |
| Effect: | modulate |
| Effect Info: | "Kurarinone inhibits the phosphorylation level of STAT1, thereby reducing the differentiation of Th1 cells and the expression of the inflammatory factor IFN-γ, and alleviating the joint inflammatory response." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 33924467 |
| Sentence Index: | 33924467_8-9 |
| Sentence: | "Results showed that kurarinone treatment reduced arthritis severity of CIA mice, as well as their levels of proinflammatory cytokines, TNF-alpha, IL-6, IFN-gamma, and IL-17A, in the serum and paw tissues. T cell proliferation was also reduced by kurarinone even under the stimulation of CII and anti-CD3 antibody." |
Sequence & Structure:
MSQWFELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIYNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEQEIKTLEELQDEYDFKCKTSQNREGEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQTWFTIVAETLQQIRQQLKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKSRLLVKLQESNLLTKVKCHFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAELRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKNDLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEMSRIVGPEFDSMMSTV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
