| Id: | acc3548 |
| Group: | 2sens |
| Protein: | TBK1 |
| Gene Symbol: | TBK1 |
| Protein Id: | Q9UHD2 |
| Protein Name: | TBK1_HUMAN |
| PTM: | Phosphorylation |
| Site: | Ser172 |
| Site Sequence: | ELEDDEQFVSLYGTEEYLHPD |
| Disease Category: | Infectious diseases |
| Disease: | RNA Virus Infection |
| Disease Subtype: | |
| Disease Cellline: | DF-2 |
| Disease Info: | |
| Drug: | VP3 protein |
| Drug Info: | The VP3 protein is a type of protein that may have potential applications in the field of medicine. |
| Effect: | modulate |
| Effect Info: | Avibirnavirus VP3 inhibits antiviral innate immunity by blocking the formation of the TBK1-TRAF3 complex and the activation of IRF4. |
| Note: | |
| Score: | 3.0 |
| Pubmed(PMID): | 33975961 |
| Sentence Index: | 33975961_6-7 |
| Sentence: | "Subsequently, we revealed that VP3 blocked TRAF3-TBK1 complex formation through reducing K33-linked polyubiquitination of lysine-155 on TRAF3. Taken together, our data reveal that VP3 inhibits MDA5-dependent IRF3-mediated signaling via blocking TRAF3-TBK1 complex formation, which improves our understanding of the interplay between RNA virus infection and the innate host antiviral immune response." |
Sequence & Structure:
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
