| Id: | acc3553 |
| Group: | 2sens |
| Protein: | GSK3beta |
| Gene Symbol: | gsk-3 |
| Protein Id: | Q9H0C8 |
| Protein Name: | ILKAP_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser9 |
| Site Sequence: | -MDLFGDLPEPERSPRPAAGK |
| Disease Category: | Nervous system diseases |
| Disease: | Alzheimer's Disease |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | EBR + ROSC |
| Drug Info: | EBR is a drug with its own specific pharmacological effects and applications. ROSC is also a drug with its unique properties and functions. | The combination of EBR and ROSC might be used for a specific treatment purpose. |
| Effect: | inhibit |
| Effect Info: | "EBR and ROSC exert neuroprotective effects by inhibiting the phosphorylation of GSK3β at the Ser9 site, effectively preventing the paralysis caused by Aβ42 toxicity in the C. elegans Alzheimer's disease model." |
| Note: | drug comb |
| Score: | 4.0 |
| Pubmed(PMID): | 34386848 |
| Sentence Index: | 34386848_11-12 |
| Sentence: | "More interestingly, the paralysis phenotype of the C. elegans AD model due to Abeta42 toxicity was prevented by EBR and/or ROSC. Our findings suggest that EBR and ROSC administration have neuroprotective effects on both in vitro and C. elegans models via inhibitory GSK3beta phosphorylation at Ser9." |
Sequence & Structure:
MDLFGDLPEPERSPRPAAGKEAQKGPLLFDDLPPASSTDSGSGGPLLFDDLPPASSGDSGSLATSISQMVKTEGKGAKRKTSEEEKNGSEELVEKKVCKASSVIFGLKGYVAERKGEREEMQDAHVILNDITEECRPPSSLITRVSYFAVFDGHGGIRASKFAAQNLHQNLIRKFPKGDVISVEKTVKRCLLDTFKHTDEEFLKQASSQKPAWKDGSTATCVLAVDNILYIANLGDSRAILCRYNEESQKHAALSLSKEHNPTQYEERMRIQKAGGNVRDGRVLGVLEVSRSIGDGQYKRCGVTSVPDIRRCQLTPNDRFILLACDGLFKVFTPEEAVNFILSCLEDEKIQTREGKSAADARYEAACNRLANKAVQRGSADNVTVMVVRIGH
No data.
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
