Id: | acc3560 |
Group: | 2sens |
Protein: | Drp1 |
Gene Symbol: | Dnm1l |
Protein Id: | Q8K1M6 |
Protein Name: | DNM1L_MOUSE |
PTM: | phosphorylation |
Site: | Ser616 |
Site Sequence: | SKPIPIMPASPQKGHAVNLLD |
Disease Category: | Cancer |
Disease: | Colorectal Cancer |
Disease Subtype: | Colorectal Adenocarcinoma |
Disease Cellline: | MC38 |
Disease Info: | |
Drug: | PD-1 Positive |
Drug Info: | PD-1 Positive is a drug that likely pertains to a positive condition or state related to the PD - 1 pathway. It may be used in the context of immunotherapy. |
Effect: | modulate |
Effect Info: | "PD-1 signaling inhibits the phosphorylation of serine 616 (Ser616) of Drp1 protein (mediated by the ERK/mTOR pathway), blocks mitochondrial fission, and thereby induces T cell exhaustion." |
Note: | Non-conventional drugs |
Score: | 3.0 |
Pubmed(PMID): | 34535949 |
Sentence Index: | 34535949_5-6 |
Sentence: | "Also, PD-1pos lymphocytic elements infiltrating a human colon cancer rarely express active Drp1. Mechanistically, PD-1 signaling directly prevents mitochondrial fragmentation following T-cell stimulation by downregulating Drp1 phosphorylation on Ser616, via regulation of the ERK1/2 and mTOR pathways." |
Sequence & Structure:
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.