Id: acc3560
Group: 2sens
Protein: Drp1
Gene Symbol: Dnm1l
Protein Id: Q8K1M6
Protein Name: DNM1L_MOUSE
PTM: phosphorylation
Site: Ser616
Site Sequence: SKPIPIMPASPQKGHAVNLLD
Disease Category: Cancer
Disease: Colorectal Cancer
Disease Subtype: Colorectal Adenocarcinoma
Disease Cellline: MC38
Disease Info:
Drug: PD-1 Positive
Drug Info: PD-1 Positive is a drug that likely pertains to a positive condition or state related to the PD - 1 pathway. It may be used in the context of immunotherapy.
Effect: modulate
Effect Info: "PD-1 signaling inhibits the phosphorylation of serine 616 (Ser616) of Drp1 protein (mediated by the ERK/mTOR pathway), blocks mitochondrial fission, and thereby induces T cell exhaustion."
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 34535949
Sentence Index:
Sentence:

Sequence & Structure:

MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGKLIQDNRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: