| Id: | acc3565 |
| Group: | 2sens |
| Protein: | cGMP |
| Gene Symbol: | PRKG1 |
| Protein Id: | Q13237 |
| Protein Name: | KGP2_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser16 |
| Site Sequence: | KPKHSKHPDGHSGNLTTDALR |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Atherosclerosis? |
| Disease Subtype: | Atherosclerotic Cardiomyopathy |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | BGP-15 |
| Drug Info: | BGP - 15 is a drug with potential therapeutic applications. It may play a role in certain medical treatments. |
| Effect: | modulate |
| Effect Info: | "BGP-15 activates the PKG pathway, promotes the phosphorylation of N2B-titin, and upregulates the ratio of the N2BA/N2B subtypes, thereby reducing myocardial passive tension and improving diastolic function." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 34811751 |
| Sentence Index: | 34811751_10-11 |
| Sentence: | "Cardiomyocyte passive tension reduced in BGP-15-treated rabbits, the ratio of titin N2BA/N2B isoforms increased, and PKG-dependent N2B-titin phosphorylation elevated in the BGP-15-treated group. CONCLUSIONS AND IMPLICATIONS: Here we report that BGP-15-treatment improves diastolic function, reduces cardiomyocyte stiffness, and restores titin compliance in a rabbit model of atherosclerotic cardiomyopathy by increasing the activity of the cGMP-PKG axis." |
Sequence & Structure:
MGNGSVKPKHSKHPDGHSGNLTTDALRNKVTELERELRRKDAEIQEREYHLKELREQLSKQTVAIAELTEELQNKCIQLNKLQDVVHMQGGSPLQASPDKVPLEVHRKTSGLVSLHSRRGAKAGVSAEPTTRTYDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVGTFEELQKYLEGYVANLNRDDEKRHAKRSMSNWKLSKALSLEMIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKGMPPDELSGWDKDF
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
