Id: | acc3570 |
Group: | 2sens |
Protein: | ERK1 |
Gene Symbol: | Mapk3 |
Protein Id: | Q63844 |
Protein Name: | MK03_MOUSE |
PTM: | phosphorylation |
Site: | Tyr204 |
Site Sequence: | EHDHTGFLTEYVATRWYRAPE |
Disease Category: | Cardiovascular and circulatory system diseases |
Disease: | Cardiac Hypertrophy |
Disease Subtype: | |
Disease Cellline: | C57BL/6J mouse |
Disease Info: | |
Drug: | sarpogrelate |
Drug Info: | Sarpogrelate is a drug that is commonly used to improve chronic arterial occlusion symptoms and microcirculation. It helps in treating related vascular diseases. |
Effect: | modulate |
Effect Info: | "Sarpogrelate inhibits TAC-induced phosphorylation of ERK1/2 and GATA4, thereby suppressing the development of heart failure." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 34959669 |
Sentence Index: | 34959669_5-6 |
Sentence: | "Immunofluorescence staining showed that sarpogrelate suppressed the cardiomyocyte hypertrophy induced by each of the stimuli. Western blotting analysis revealed that 5-HT2A receptor level was not changed by phenylephrine, and that sarpogrelate suppressed phenylephrine-induced phosphorylation of ERK1/2 and GATA4." |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEGP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
T | 203 | U | Squamous cell carcinoma | Phosphorylation | 19934324 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.