| Id: | acc3573 |
| Group: | 2sens |
| Protein: | GATA4 |
| Gene Symbol: | Gata4 |
| Protein Id: | Q08369 |
| Protein Name: | GATA4_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser105 |
| Site Sequence: | GAAYTPPPVSPRFSFPGTTGS |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiac Hypertrophy |
| Disease Subtype: | |
| Disease Cellline: | C57BL/6J mouse |
| Disease Info: | |
| Drug: | sarpogrelate |
| Drug Info: | Sarpogrelate is a drug that is commonly used to improve chronic arterial occlusion symptoms and microcirculation. It helps in treating related vascular diseases. |
| Effect: | modulate |
| Effect Info: | "Sarpogrelate inhibits TAC-induced phosphorylation of ERK1/2 and GATA4, thereby suppressing the development of heart failure." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 34959669 |
| Sentence Index: | 34959669_5-6 |
| Sentence: | "Immunofluorescence staining showed that sarpogrelate suppressed the cardiomyocyte hypertrophy induced by each of the stimuli. Western blotting analysis revealed that 5-HT2A receptor level was not changed by phenylephrine, and that sarpogrelate suppressed phenylephrine-induced phosphorylation of ERK1/2 and GATA4." |
Sequence & Structure:
MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSAAAAGTTSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYGSGGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPGRHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPAGETLPPSSGASSGNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGPSIHPVLSALKLSPQGYASPVTQTSQASSKQDSWNSLVLADSHGDIITA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
