| Id: | acc3581 |
| Group: | 2sens |
| Protein: | IkappaBalpha |
| Gene Symbol: | Nfkbia |
| Protein Id: | Q9Z1E3 |
| Protein Name: | IKBA_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser32 |
| Site Sequence: | ERLVDDRHDSGLDSMKDEEYE |
| Disease Category: | Digestive system diseases |
| Disease: | Colitis |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | IRAK1/4 inhibitor |
| Drug Info: | IRAK1/4 inhibitor is a type of drug that inhibits the activity of IRAK1 and IRAK4. It may play a role in relevant disease treatment by interfering with the corresponding signaling pathways. |
| Effect: | modulate |
| Effect Info: | "Inhibition of IRAK1/4 suppresses the NF-κB pathway by blocking IκBα phosphorylation, thereby alleviating colitis." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 35699749 |
| Sentence Index: | 35699749_8-9 |
| Sentence: | "Investigations showed that the IRAK 1/4 inhibitor significantly reduced clinical symptoms and pathological DSS-induced colitis damage in mice and then inhibited the cytoplasmic and nuclear translocation of NF-kappaB p65, including the phosphorylation of IkappaBalpha and reduction in downstream inflammatory factor production. Therefore, we established that the IRAK1/4 inhibitor effectively improves colitis induced by DSS, partly by inhibiting the TLR4/NF-kappaB pathway, reducing inflammation, and maintaining the integrity of the colonic barrier." |
Sequence & Structure:
MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEEYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKPLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLAIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
