Id: | acc3587 |
Group: | 2sens |
Protein: | AMPKalpha |
Gene Symbol: | Prkaa1 |
Protein Id: | Q5EG47 |
Protein Name: | AAPK1_MOUSE |
PTM: | phosphorylation |
Site: | Thr172 |
Site Sequence: | NAKIADFGLSNMMSDGEFLRT |
Disease Category: | Cancer |
Disease: | Lung Cancer |
Disease Subtype: | Lewis xenogeneic mouse? |
Disease Cellline: | Lewis |
Disease Info: | |
Drug: | Yifei sanjie Pills(YFSJ) |
Drug Info: | Yifei sanjie Pills (YFSJ) is a drug that is described here. It may have certain therapeutic effects in relevant medical fields. |
Effect: | modulate |
Effect Info: | "YFSJ alleviates DDP chemotherapy-related fatigue by reducing oxidative stress, inhibiting the activation of the AMPK/mTOR pathway, decreasing the expression of autophagy-related proteins, and mitigating apoptosis." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 36045663 |
Sentence Index: | 36045663_11-12 |
Sentence: | "It was also found that YFSJ reduced the loss of body weight caused by DDP, reversed the ascent of serum concentrations of alanine aminotransferase (ALT), aminotransferase (AST), and creatinine (CREA), increased the spleen index, and prolonged the survival time of mice. Taken together, these results revealed that YFSJ could alleviate CRF by reducing mitophagy and apoptosis induced by oxidative stress in skeletal muscle; these results also displayed the effects of YFSJ on enhancing chemotherapy sensitivity, improving quality of life, and prolonging survival time in lung cancer mice received DDP chemotherapy." |
Sequence & Structure:
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSDVSLTSSVTSLDSSPVDVAPRPGSHTIEFFEMCANLIKILAQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.