| Id: | acc3592 |
| Group: | 2sens |
| Protein: | Raf-1 |
| Gene Symbol: | Raf1 |
| Protein Id: | Q99N57 |
| Protein Name: | RAF1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser301 |
| Site Sequence: | ALSSSPNNLSPTGWSQPKTPV |
| Disease Category: | Other |
| Disease: | Heterologous Desensitization |
| Disease Subtype: | Opioid tolerance or analgesic failure |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | delta opioid receptor |
| Drug Info: | The delta opioid receptor is a type of opioid receptor involved in modulating pain perception and other physiological processes. It plays a crucial role in the body's response to certain analgesic drugs. |
| Effect: | inhibit |
| Effect Info: | Phosphorylation of Raf-1 (Ser289/296/301) directly reduces the analgesic sensitivity of DOR agonists. |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 36525124 |
| Sentence Index: | 36525124_4-5 |
| Sentence: | "Moreover, CHA exposure time-dependently induced the phosphorylation of Raf-1-Ser289/296/301, the inhibitory phosphorylation sites that were regulated by negative feedback, thereby inhibiting activation of the MEK/ERK pathway, and this effect could be blocked by MEK inhibitor U0126. Finally, we proved that the heterologous desensitization of the Raf-1/MEK/ERK cascade was essential in the regulation of anti-nociceptive effect of DOR agonists by confirming that such effect was inhibited by pretreatment of CHA." |
Sequence & Structure:
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTVGDSGVPAPPSFPMRRMRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLHVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
