Id: acc3596
Group: 2sens
Protein: HMGB1
Gene Symbol: HMGB1
Protein Id: P09429
Protein Name: HMGB1_HUMAN
PTM: acetylation
Site: Lys29
Site Sequence: VQTCREEHKKKHPDASVNFSE
Disease Category: Immune system diseases
Disease: Kidney Damage
Disease Subtype: TCE-induced immune kidney damage
Disease Cellline:
Disease Info:
Drug: FPS–ZM 1
Drug Info: "FPS–ZM 1 is a specific drug, but no detailed information about its properties is provided in the given text."
Effect: modulate
Effect Info: The drug inhibited protein acetylation and alleviated podocyte damage.
Note:
Score: 4.0
Pubmed(PMID): 37216866
Sentence Index:
Sentence:

Sequence & Structure:

MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
HMGB1 CD24FC High mobility group protein B1 inhibitor 3 Completed COVID-19 ClinicalTrials
HMGB1 CD24FC High mobility group protein B1 inhibitor 1 Terminated neoplasm ClinicalTrials
HMGB1 CD24FC High mobility group protein B1 inhibitor 1 Withdrawn metastatic melanoma ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
HMGB1-Lys29
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
K 29 D Sepsis-associated acute kidney injury Acetylation 30379096
K 29 U Sepsis Acetylation 34363018

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: