| Id: | acc3599 |
| Group: | 2sens |
| Protein: | MKK4? |
| Gene Symbol: | Map2k4 |
| Protein Id: | P47809 |
| Protein Name: | MP2K4_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser257 |
| Site Sequence: | ISGQLVDSIAKTRDAGCRPYM |
| Disease Category: | Digestive system diseases |
| Disease: | Acute Liver Failure |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Fluorofenidone?(AKF-PD) |
| Drug Info: | Fluorofenidone (AKF - PD) is a drug that has been the subject of medical research. It may have potential applications in treating certain diseases. |
| Effect: | modulate |
| Effect Info: | "AKF-PD can inhibit the phosphorylation of MKK4, block the JNK signaling pathway, reduce ROS accumulation, mitochondrial damage and apoptosis, and exert a hepatoprotective effect." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 37224750 |
| Sentence Index: | 37224750_10-11 |
| Sentence: | "In vitro and in vivo studies demonstrated that AKF-PD inhibited APAP-induced phosphorylation of MKK4/JNK, while SP600125 only inhibited JNK phosphorylation. The protective effect of AKF-PD was abolished by anisomycin." |
Sequence & Structure:
MAAPSPSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGKRKALKLNFANPPVKSTARFTLNPNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
