PMADS

Id:	acc3600
Group:	2sens
Protein:	Akt
Gene Symbol:	Akt1
Protein Id:	P31750
Protein Name:	AKT1_MOUSE
PTM:	phosphorylation
Site:	Thr450
Site Sequence:	EFTAQMITITPPDQDDSMECV
Disease Category:	Digestive system diseases
Disease:	Colitis
Disease Subtype:
Disease Cellline:
Disease Info:
Drug:	GPS extract
Drug Info:	GPS extract is a drug. It can potentially be used for relevant medical purposes.
Effect:	modulate
Effect Info:	Drug (GPS extract) → Inhibition of protein phosphorylation (Akt/p38/ERK/JNK) → Alleviation of colitis
Note:
Score:	4.0
Pubmed(PMID):	37249930
Sentence Index:	37249930_9-10
Sentence:	"Network pharmacology integrated with experimental validation identified that GPS extract significantly suppressed Akt, p38, ERK, and JNK phosphorylation in vivo and in vitro, and luteolin, apocynin, caffeic acid, caffeic acid methyl ester, luteoloside, picroside II, aucubin, cinnamic acid, vanillic acid, and sweroside were the main components responsible for the anti-inflammatory effect of GPS. These findings demonstrate that the potential anti-inflammatory effect of GPS extract against colitis is achieved through suppressing PI3K/Akt and MAPK pathways, and that the abovementioned active components mainly exerted its anti-inflammatory effect."

Sequence & Structure:

MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

Residue	Position	State	Disease	Class	PMID
S	473	D	Alzheimer's disease	Phosphorylation	35834993 ; 36843923
S	473	D	Colonic inflammation	Phosphorylation	36735734
S	473	D	Diabetes mellitus	Phosphorylation	17130464 ; 16777975 ; 15033922 ; 15033922 ; 16777975 ; 17130464 ; 35739993
S	473	D	Turner syndrome	Phosphorylation	33910978
-	-	D	Alzheimer's disease	Phosphorylation	37651754
-	-	P	Brain cancer	Phosphorylation	15026334
S	473	U	Cardiomyopathy	Phosphorylation	35358489
S	473	U	Diabetes mellitus	Phosphorylation	35358489
S	473	U	Endometrial cancer/carcinoma	Phosphorylation	16585156
T	308	U	Prostate cancer	Phosphorylation	37384528
T	308	U	Hepatocellular carcinoma	Phosphorylation	33500384
Y	176	U	Prostate cancer/carcinoma/adenocarcinoma	Phosphorylation	20333297
S	473	U	Melanoma	Phosphorylation	26565903
S	473	U	Non-small cell lung cancer	Phosphorylation	35961388
S	473	U	Hepatocellular carcinoma	Phosphorylation	33500384

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb