PMADS

Id:	acc3606
Group:	2sens
Protein:	JNK
Gene Symbol:	Mapk8
Protein Id:	Q91Y86
Protein Name:	MK08_MOUSE
PTM:	phosphorylation
Site:	Tyr185
Site Sequence:	AGTSFMMTPYVVTRYYRAPEV
Disease Category:	Digestive system diseases
Disease:	Colitis
Disease Subtype:
Disease Cellline:
Disease Info:
Drug:	GPS extract
Drug Info:	GPS extract is a drug. It can potentially be used for relevant medical purposes.
Effect:	modulate
Effect Info:	Drug (GPS extract) → Inhibition of protein phosphorylation (Akt/p38/ERK/JNK) → Alleviation of colitis
Note:
Score:	4.0
Pubmed(PMID):	37249930
Sentence Index:	37249930_9-10
Sentence:	"Network pharmacology integrated with experimental validation identified that GPS extract significantly suppressed Akt, p38, ERK, and JNK phosphorylation in vivo and in vitro, and luteolin, apocynin, caffeic acid, caffeic acid methyl ester, luteoloside, picroside II, aucubin, cinnamic acid, vanillic acid, and sweroside were the main components responsible for the anti-inflammatory effect of GPS. These findings demonstrate that the potential anti-inflammatory effect of GPS extract against colitis is achieved through suppressing PI3K/Akt and MAPK pathways, and that the abovementioned active components mainly exerted its anti-inflammatory effect."

Sequence & Structure:

MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb