| Id: | acc3626 |
| Group: | 2sens_supp |
| Protein: | p53 |
| Gene Symbol: | Tp53 |
| Protein Id: | P02340 |
| Protein Name: | P53_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser15 |
| Site Sequence: | ESQSDISLELPLSQETFSGLW |
| Disease Category: | Cancer |
| Disease: | Lung Cancer |
| Disease Subtype: | Lewis xenogeneic mouse? |
| Disease Cellline: | Lewis |
| Disease Info: | |
| Drug: | Yifei sanjie Pills(YFSJ) + DDP |
| Drug Info: | "Yifei sanjie Pills(YFSJ) is one type of drug | DDP is another drug, and they are used in combination. " |
| Effect: | modulate |
| Effect Info: | "It showed the effects of YFSJ on enhancing chemotherapy sensitivity, improving the quality of life, and prolonging the survival time of lung cancer mice receiving DDP chemotherapy." |
| Note: | drug comb |
| Score: | 4.0 |
| Pubmed(PMID): | 36045663 |
| Sentence Index: | 36045663_11-12_supp |
| Sentence: | "Consistently, xenografts treated with DDP or YFSJ alone both displayed activated cell apoptosis and autophagy, while the combined treatment of DDP?+?YFSJ showed the most potent effects (Figures 4(e)–4(h)), as evidenced by activation of the JNK/p53 pathway, increasing Bax, c-Casp 3, c-PARP, Beclin1, Atg7, and LC3B and reducing p62 in protein expression levels. In conclusion, YFSJ has an inhibitory effect on tumor growth and is synergistic with the antitumor effect of DDP." |
Sequence & Structure:
MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
