| Id: | acc3653 |
| Group: | 1sens |
| Protein: | Rhodopsin |
| Gene Symbol: | Rho |
| Protein Id: | P51489 |
| Protein Name: | OPSD_RAT |
| PTM: | Phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Eye diseases |
| Disease: | Retinal Dysfunction |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Nilvadipine |
| Drug Info: | Nilvadipine is a calcium channel blocker used in the treatment of hypertension. It helps to relax blood vessels and lower blood pressure. |
| Effect: | modulate |
| Effect Info: | Nilvadipine significantly improved the recoverin antibody-induced retinal dysfunction by reducing the phosphorylation level of rhodopsin. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 11581204 |
| Sentence Index: | 11581204_7 |
| Sentence: | "Administration of nilvadipine, a Ca(2+) antagonist, to the anti-recoverin antibody-treated rats and rats with phototoxic retinal dysfunction caused significant improvement of the deterioration of ERG and normalization of rhodopsin phosphorylation." |
Sequence & Structure:
MNGTEGPNFYVPFSNITGVVRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAMYIFTHQGSNFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSLCCGKNPLGDDEASATASKTETSQVAPA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
