Id: acc3654
Group: 1sens
Protein: Akt
Gene Symbol: Akt1
Protein Id: P31750
Protein Name: AKT1_MOUSE
PTM: phosphorylation
Site: Ser473
Site Sequence: ERRPHFPQFSYSASGTA----
Disease Category: Cancer
Disease: Pancreatic Cancer
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: Gemcitabine
Drug Info: "Gemcitabine is a chemotherapy drug used to treat various types of cancer, such as pancreatic, lung, and breast cancer."
Effect: inhibit
Effect Info: "Wortmannin can inhibit the phosphorylation of PKB/AKT protein, thereby promoting the anti - tumor activity of the chemotherapeutic drug gemcitabine in a pancreatic cancer xenograft model in immunodeficient mice."
Note:
Score: 5.0
Pubmed(PMID): 11595724
Sentence Index:
Sentence:

Sequence & Structure:

MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 473 D Alzheimer's disease Phosphorylation 35834993 ;  36843923
S 473 D Colonic inflammation Phosphorylation 36735734
S 473 D Diabetes mellitus Phosphorylation 17130464 ;  16777975 ;  15033922 ;  15033922 ;  16777975 ;  17130464 ;  35739993
S 473 D Turner syndrome Phosphorylation 33910978
S 473 U Cardiomyopathy Phosphorylation 35358489
S 473 U Diabetes mellitus Phosphorylation 35358489
S 473 U Endometrial cancer/carcinoma Phosphorylation 16585156
S 473 U Melanoma Phosphorylation 26565903
S 473 U Non-small cell lung cancer Phosphorylation 35961388
S 473 U Hepatocellular carcinoma Phosphorylation 33500384

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: