| Id: | acc3655 |
| Group: | 1sens |
| Protein: | Akt |
| Gene Symbol: | Akt1 |
| Protein Id: | P47196 |
| Protein Name: | AKT1_RAT |
| PTM: | phosphorylation |
| Site: | Thr308 |
| Site Sequence: | GIKDGATMKTFCGTPEYLAPE |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | Diabetic Heart Disease |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | islet-transplanted |
| Drug Info: | "“Islet - transplanted” refers to a process or state where islets have been transplanted. It is often related to medical treatments for diabetes, aiming to restore normal insulin - producing function." |
| Effect: | modulate |
| Effect Info: | "The phosphorylation level of Akt at the Thr - 308 site in diabetic rats was 5 - fold higher than that in the control group. Although it decreased after transplantation compared with the diabetic group, it was still higher than that in the control group." |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 11723053 |
| Sentence Index: | 11723053_4 |
| Sentence: | "Insulin-induced phosphorylation of Akt on Thr-308 was increased fivefold in diabetic heart, whereas Akt phosphorylation on Ser-473 was normal." |
Sequence & Structure:
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 308 | D | Obesity | Phosphorylation | 16267124 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
