| Id: | acc3660 |
| Group: | 1sens |
| Protein: | p52(Shc) |
| Gene Symbol: | Shc3 |
| Protein Id: | O70143 |
| Protein Name: | SHC3_RAT |
| PTM: | phosphorylation |
| Site: | Tyr |
| Site Sequence: | |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | Diabetic Heart Disease |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | islet-transplanted |
| Drug Info: | "“Islet - transplanted” refers to a process or state where islets have been transplanted. It is often related to medical treatments for diabetes, aiming to restore normal insulin - producing function." |
| Effect: | modulate |
| Effect Info: | The tyrosine phosphorylation level of p52^Shc in diabetic rats was elevated under insulin stimulation and returned to normal after transplantation. |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 11723053 |
| Sentence Index: | 11723053_4 |
| Sentence: | "Insulin-induced phosphorylation of Akt on Thr-308 was increased fivefold in diabetic heart, whereas Akt phosphorylation on Ser-473 was normal." |
Sequence & Structure:
MLPRTKYNRFRNDSVTSVDDLLHSLSVSGSGGKVSAEPAASPYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSAPSLAAPDGGSATPGSRAPAASMSATRKSRASDEPLPRPPRGAPHASDQVLGSGVTYVVKYLGCIEVLRSMRSLDFSTRTQVTREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNLQFAGMSISLTISTASLNLRTPDSKQIISNHHMRSISFASGGDPDTTDYVAYVAKDPVNRRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPSKIPALQDRMQSLDEPWTEEEGDGPDHPYYNSVPNKMPPPGGFLDARLKARPHAPDAAQFSGKEQTYYQGRHLGDAFGEDWQRAPTRQGSLDIYSTPEGKAHMVPVGETPTYVNTQPVPPQVWPAATSSTESSPRKDLFDMKPFEDALRNQPLGPVLSKAASVECISPVTPRAPDAKMLEELNAEPWYQGEMSRKEAEALLQEDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTVRTKDRVFDSISHLITYHLESSLPIVSAGSELCLRQPVERKP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
