Id: acc3670
Group: 1sens
Protein: CREB
Gene Symbol: Creb1
Protein Id: Q01147
Protein Name: CREB1_MOUSE
PTM: phosphorylation
Site: Ser133
Site Sequence: LNDLSSDAPGVPRIEEEKSEE
Disease Category: Other
Disease: Embryonic Palatal Issue
Disease Subtype:
Disease Cellline: MEPM cells
Disease Info:
Drug: forskolin
Drug Info: "Forskolin is a naturally - occurring compound used in some medications and supplements, which may have effects on various physiological processes."
Effect: modulate
Effect Info: "In mouse embryonic palatal mesenchymal cells, the drug forskolin increased the phosphorylation of CREB at Ser133."
Note:
Score: 3.0
Pubmed(PMID): 12175701
Sentence Index:
Sentence:

Sequence & Structure:

MTMESGADNQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 133 D Type 2 diabetes Phosphorylation 34193609
S 133 N Heart failure Phosphorylation 17616745

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: