Id: acc3678
Group: 1sens
Protein: Akt
Gene Symbol: Akt1
Protein Id: P47196
Protein Name: AKT1_RAT
PTM: phosphorylation
Site: Ser473
Site Sequence: ERRPHFPQFSYSASGTA----
Disease Category: Endocrine and metabolic diseases
Disease: Obese
Disease Subtype: insulin resistance
Disease Cellline:
Disease Info:
Drug: losartan
Drug Info: Losartan is an angiotensin II receptor blocker used to treat high blood pressure and reduce the risk of stroke in patients with high blood pressure and an enlarged heart.
Effect: modulate
Effect Info: Losartan attenuated the reduction of Akt phosphorylation in the hearts of obese rats and alleviated insulin resistance.
Note:
Score: 4.0
Pubmed(PMID): 12960006
Sentence Index:
Sentence:

Sequence & Structure:

MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 473 D Major depressive disorder Phosphorylation 16959794
S 473 D Type 2 diabetes Phosphorylation 34057658 ;  36374861
S 473 U Status epilepticus Phosphorylation 35562960

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: