Id: | acc3681 |
Group: | 1sens |
Protein: | CREB |
Gene Symbol: | Creb1 |
Protein Id: | P15337 |
Protein Name: | CREB1_RAT |
PTM: | phosphorylation |
Site: | Ser133 |
Site Sequence: | LNDLSSDAPGVPRIEEEKSEE |
Disease Category: | Nervous system diseases |
Disease: | Neuronal Damage |
Disease Subtype: | |
Disease Cellline: | |
Disease Info: | |
Drug: | cilostazol |
Drug Info: | "Cilostazol is a medication used to treat intermittent claudication, which helps increase walking distance by improving blood flow in the legs." |
Effect: | modulate |
Effect Info: | "The drug inhibits apoptotic cell death by upregulating CK2 phosphorylation and downregulating PTEN phosphorylation, thereby increasing the phosphorylation of Akt and CREB and increasing the Bcl-2 protein, thus improving neuronal damage." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 14634032 |
Sentence Index: | 14634032_6 |
Sentence: | "In conclusion, cilostazol ameliorates the neuronal damage by suppression of apoptotic cell death via the maxi-K channel opening-coupled up-regulation of CK2 phosphorylation and down-regulation of PTEN phosphorylation with resultant increase in the Akt and CREB phosphorylation and increased Bcl-2 protein." |
Sequence & Structure:
MTMDSGADNQQSGDAAVTEAESQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
S | 133 | U | Pulmonary hypertension | Phosphorylation | 34635097 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.