| Id: | acc3684 |
| Group: | 1sens |
| Protein: | PTEN |
| Gene Symbol: | Pten |
| Protein Id: | O54857 |
| Protein Name: | PTEN_RAT |
| PTM: | phosphorylation |
| Site: | Thr383 |
| Site Sequence: | PDHYRYSDTTDSDPENEPFDE |
| Disease Category: | Nervous system diseases |
| Disease: | Neuronal Damage |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | cilostazol |
| Drug Info: | "Cilostazol is a medication used to treat intermittent claudication, which helps increase walking distance by improving blood flow in the legs." |
| Effect: | modulate |
| Effect Info: | "The drug inhibits apoptotic cell death by upregulating CK2 phosphorylation and downregulating PTEN phosphorylation, thereby increasing the phosphorylation of Akt and CREB and increasing the Bcl-2 protein, thus improving neuronal damage." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 14634032 |
| Sentence Index: | 14634032_6 |
| Sentence: | "In conclusion, cilostazol ameliorates the neuronal damage by suppression of apoptotic cell death via the maxi-K channel opening-coupled up-regulation of CK2 phosphorylation and down-regulation of PTEN phosphorylation with resultant increase in the Akt and CREB phosphorylation and increased Bcl-2 protein." |
Sequence & Structure:
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKLMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
