| Id: | acc3691 |
| Group: | 1sens |
| Protein: | ERK |
| Gene Symbol: | Mapk1 |
| Protein Id: | P21708 |
| Protein Name: | MK03_RAT |
| PTM: | phosphorylation |
| Site: | Thr202 |
| Site Sequence: | DPEHDHTGFLTEYVATRWYRA |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiac Hypertrophy |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | pertussis toxin (PTX) |
| Drug Info: | "Pertussis toxin (PTX) is a protein exotoxin produced by the bacterium Bordetella pertussis, which is involved in whooping cough pathogenesis." |
| Effect: | modulate |
| Effect Info: | PTX inhibits LPA-induced ERK phosphorylation and the formation of cardiac hypertrophy phenotypes by blocking Gi protein signaling. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 15081308 |
| Sentence Index: | 15081308_5 |
| Sentence: | "Pretreatment of myocytes with pertussis toxin (PTX) not only blocks the capacity of LPA to inhibit cyclic AMP formation and stimulate ERK phosphorylationation, but also inhibits hypertrophic changes in cell morphology and ANF-luciferase gene expression." |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
