| Id: | acc3694 |
| Group: | 1sens |
| Protein: | Mdm2 |
| Gene Symbol: | Mdm2 |
| Protein Id: | P23804 |
| Protein Name: | MDM2_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser188 |
| Site Sequence: | KRRRSLSFDPSLGLCELREMC |
| Disease Category: | Cancer |
| Disease: | Tumorigenesis |
| Disease Subtype: | |
| Disease Cellline: | mouse embryonic fibroblasts |
| Disease Info: | |
| Drug: | PKB |
| Drug Info: | PKB is a drug whose properties and functions need further context for a more detailed description. |
| Effect: | modulate |
| Effect Info: | "Protein kinase B (PKB) inhibits the self-ubiquitination of Mdm2 by phosphorylating Ser(166) and Ser(188) of Mdm2, thereby stabilizing the Mdm2 protein." |
| Note: | no disease |
| Score: | 2.0 |
| Pubmed(PMID): | 15169778 |
| Sentence Index: | 15169778_4 |
| Sentence: | "Stimulation of human embryonic kidney 293 cells with insulin-like growth factor-1 increased Mdm2 phosphorylation on Ser(166) and Ser(188) in a phosphatidylinositide 3'-OH kinase-dependent manner, and the treatment of both human embryonic kidney 293 and COS-1 cells with phosphatidylinositide 3'-OH kinase inhibitor LY-294002 led to proteasome-mediated Mdm2 degradation." |
Sequence & Structure:
MCNTNMSVSTEGAASTSQIPASEQETLVRPKPLLLKLLKSVGAQNDTYTMKEIIFYIGQYIMTKRLYDEKQQHIVYCSNDLLGDVFGVPSFSVKEHRKIYAMIYRNLVAVSQQDSGTSLSESRRQPEGGSDLKDPLQAPPEEKPSSSDLISRLSTSSRRRSISETEENTDELPGERHRKRRRSLSFDPSLGLCELREMCSGGSSSSSSSSSESTETPSHQDLDDGVSEHSGDCLDQDSVSDQFSVEFEVESLDSEDYSLSDEGHELSDEDDEVYRVTVYQTGESDTDSFEGDPEISLADYWKCTSCNEMNPPLPSHCKRCWTLRENWLPDDKGKDKVEISEKAKLENSAQAEEGLDVPDGKKLTENDAKEPCAEEDSEEKAEQTPLSQESDDYSQPSTSSSIVYSSQESVKELKEETQDKDESVESSFSLNAIEPCVICQGRPKNGCIVHGKTGHLMSCFTCAKKLKKRNKPCPVCRQPIQMIVLTYFN
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
