Id: acc3696
Group: 1sens
Protein: PKC delta
Gene Symbol: Prkcd
Protein Id: P28867
Protein Name: KPCD_MOUSE
PTM: phosphorylation
Site: Thr505
Site Sequence: NIFGEGRASTFCGTPDYIAPE
Disease Category: Immune system diseases
Disease: Allergic
Disease Subtype: Lyn(-/-)
Disease Cellline: Lyn(-/-) BMMCs
Disease Info:
Drug: Lyn KO
Drug Info: "Lyn KO is a drug that might have specific effects on relevant biological pathways or diseases, but more context is needed for a detailed description."
Effect: modulate
Effect Info: "The study found that the phosphorylation level of the Src kinase Fyn was significantly increased in Lyn(–/–) BMMCs, while the phosphorylation and activity related to SHIP were significantly decreased, which may lead to an increase in the level of phosphatidylinositol 3,4,5 - trisphosphate and an enhancement of FcepsilonRI signaling. "
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 15210764
Sentence Index:
Sentence:

Sequence & Structure:

MAPFLRISFNSYELGSLQVEDEASQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKTTFDAHIYEGRVIQIVLMRAAEDPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMCVQYFLEDGDCKQSMRSEEEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRSSRKLDTTESVGIYQGFEKKPEVSGSDILDNNGTYGKIWEGSTRCTLENFTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTGNIRIHPFFKTINWSLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAFHGFSFVNPKFEQFLDI

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: