Id: acc3697
Group: 1sens
Protein: SHIP
Gene Symbol: Inpp5d
Protein Id: Q92835
Protein Name: SHIP1_HUMAN
PTM: phosphorylation
Site: Tyr1020
Site Sequence: LTKPEMFENPLYGSLSSFPKP
Disease Category: Immune system diseases
Disease: Allergic
Disease Subtype: Lyn(-/-)
Disease Cellline: Lyn(-/-) BMMCs
Disease Info:
Drug: Lyn KO
Drug Info: "Lyn KO is a drug that might have specific effects on relevant biological pathways or diseases, but more context is needed for a detailed description."
Effect: modulate
Effect Info: "The study found that the phosphorylation level of the Src kinase Fyn was significantly increased in Lyn(–/–) BMMCs, while the phosphorylation and activity related to SHIP were significantly decreased, which may lead to an increase in the level of phosphatidylinositol 3,4,5 - trisphosphate and an enhancement of FcepsilonRI signaling. "
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 15210764
Sentence Index:
Sentence:

Sequence & Structure:

MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESVVSPPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEANPINMVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKLIIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYRDNTELPHHGKHRPEEGPPGPLGRTAMQ

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
INPP5D ROSIPTOR Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 activator 3 Unknown status interstitial cystitis ClinicalTrials
INPP5D ROSIPTOR Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 activator 3 Unknown status chronic interstitial cystitis ClinicalTrials
INPP5D ROSIPTOR Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 activator 2 Completed atopic eczema ClinicalTrials
INPP5D ROSIPTOR Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 activator 2 Completed chronic obstructive pulmonary disease ClinicalTrials
INPP5D ROSIPTOR Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 activator 2 Completed interstitial cystitis ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: