| Id: | acc3706 |
| Group: | 1sens |
| Protein: | Akt |
| Gene Symbol: | Akt1 |
| Protein Id: | P47196 |
| Protein Name: | AKT1_RAT |
| PTM: | phosphorylation |
| Site: | |
| Site Sequence: | |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Myocardial Ischemic Injury |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | dehydroascorbic acid (DHA) |
| Drug Info: | Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid. It can play various roles in biological systems. |
| Effect: | modulate |
| Effect Info: | "DHA reduces cardiomyocyte apoptosis and has a protective effect against myocardial ischemia in rats by inhibiting protein phosphorylation (e.g., phosphorylation of Jak2, STAT1, and STAT5b), increasing the phosphorylation of anti - apoptotic proteins (e.g., Bcl - 2, Bcl - xl), and suppressing the activation of apoptosis - related proteins (e.g., Bax, caspase - 3). " |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 15454281 |
| Sentence Index: | 15454281_8 |
| Sentence: | "DHA treatment also inhibited Jak2, STAT1, and STAT5 phosphorylationation, and increased STAT3 phosphorylationation, in hypoxic cardiomyocytes and ischemic myocardial tissue." |
Sequence & Structure:
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 473 | D | Major depressive disorder | Phosphorylation | 16959794 |
| S | 473 | D | Type 2 diabetes | Phosphorylation | 34057658 ; 36374861 |
| T | 308 | D | Obesity | Phosphorylation | 16267124 |
| S | 473 | U | Status epilepticus | Phosphorylation | 35562960 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
