Id: acc3708
Group: 1sens
Protein: STAT1
Gene Symbol: Stat1
Protein Id: P42224
Protein Name: STAT1_HUMAN
PTM: phosphorylation
Site: unclear
Site Sequence:
Disease Category: Cardiovascular and circulatory system diseases
Disease: Myocardial Ischemic Injury
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: dehydroascorbic acid (DHA)
Drug Info: Dehydroascorbic acid (DHA) is an oxidized form of ascorbic acid. It can play various roles in biological systems.
Effect: modulate
Effect Info: "DHA reduces cardiomyocyte apoptosis and has a protective effect against myocardial ischemia in rats by inhibiting protein phosphorylation (e.g., phosphorylation of Jak2, STAT1, and STAT5b), increasing the phosphorylation of anti - apoptotic proteins (e.g., Bcl - 2, Bcl - xl), and suppressing the activation of apoptosis - related proteins (e.g., Bax, caspase - 3). "
Note:
Score: 4.0
Pubmed(PMID): 15454281
Sentence Index:
Sentence:

Sequence & Structure:

MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
- - D Melanoma Phosphorylation 12421984
- - D Lymphoma Phosphorylation 12421984
- - D Esophageal carcinoma Ubiquitination 30506884
- - P Neuroblastoma Phosphorylation 14982729
- - P Epidermoid carcinoma Phosphorylation 23178573
- - P Oral squamous cell carcinoma Phosphorylation 23992782
- - U Glioma Acetylation 34784299
- - U Chronic colitis Phosphorylation 37211384
- - U Chronic lymphocytic leukemia Phosphorylation 23936412

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: