| Id: | acc3748 |
| Group: | 1sens |
| Protein: | p38 MAPK |
| Gene Symbol: | - |
| Protein Id: | Q13202 |
| Protein Name: | DUS8_HUMAN |
| PTM: | phosphorylation |
| Site: | Tyr182 |
| Site Sequence: | QKDVLNKDLMTQNGISYVLNA |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Vascular Calcification |
| Disease Subtype: | |
| Disease Cellline: | 牛血管钙化细胞系CVCs |
| Disease Info: | |
| Drug: | N-3脂肪酸（DHA） |
| Drug Info: | N-3 fatty acid (DHA) is an essential nutrient that plays a crucial role in brain and eye development. It also has potential health benefits for heart health. |
| Effect: | modulate |
| Effect Info: | N-3 fatty acid (DHA) inhibits the osteogenic differentiation and mineralization of bovine vascular calcification cell line CVCs by activating p38-MAPK and PPAR-γ. |
| Note: | ID not sure |
| Score: | 4.0 |
| Pubmed(PMID): | 16514067 |
| Sentence Index: | 16514067_0 |
| Sentence: | N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways. |
Sequence & Structure:
MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSWHVLSSVNICCSKLVKRRLQQGKVTIAELIQPAARSQVEATEPQDVVVYDQSTRDASVLAADSFLSILLSKLDGCFDSVAILTGGFATFSSCFPGLCEGKPAALLPMSLSQPCLPVPSVGLTRILPHLYLGSQKDVLNKDLMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSCQVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSLKLLAALQGDPGTPSGTPEPPPSPAAGAPLPRLPPPTSESAATGNAAAREGGLSAGGEPPAPPTPPATSALQQGLRGLHLSSDRLQDTNRLKRSFSLDIKSAYAPSRRPDGPGPPDPGEAPKLCKLDSPSGAALGLSSPSPDSPDAAPEARPRPRRRPRPPAGSPARSPAHSLGLNFGDAARQTPRHGLSALSAPGLPGPGQPAGPGAWAPPLDSPGTPSPDGPWCFSPEGAQGAGGVLFAPFGRAGAPGPGGGSDLRRREAARAEPRDARTGWPEEPAPETQFKRRSCQMEFEEGMVEGRARGEELAALGKQASFSGSVEVIEVS
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
