Id: acc3761
Group: 1sens
Protein: nNOS
Gene Symbol: NOS1
Protein Id: P29475
Protein Name: NOS1_HUMAN
PTM: phosphorylation
Site: Ser847
Site Sequence: SVQEERKSYKVRFNSVSSYSD
Disease Category: Nervous system diseases
Disease: Brain Nitric Oxide Regulation
Disease Subtype:
Disease Cellline: HEK-293
Disease Info:
Drug: EGF
Drug Info: "EGF stands for Epidermal Growth Factor, which is a protein that stimulates cell growth and differentiation."
Effect: modulate
Effect Info: "In HEK-293 cells, EGF treatment leads to an increase in the phosphorylation level of nNOS at the Ser847 site."
Note: no disease
Score: 2.0
Pubmed(PMID): 16984226
Sentence Index:
Sentence:

Sequence & Structure:

MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPPAGKEQPLAVDGASGPGNGPQHAYDDGQEAGSLPHANGLAPRPPGQDPAKKATRVSLQGRGENNELLKEIEPVLSLLTSGSRGVKGGAPAKAEMKDMGIQVDRDLDGKSHKPLPLGVENDRVFNDLWGKGNVPVVLNNPYSEKEQPPTSGKQSPTKNGSPSKCPRFLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPELTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDTDEVFSS

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
NOS1 TILARGININE ACETATE Nitric oxide synthase inhibitor 3 Terminated Shock ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 3 Terminated Shock ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 2 Terminated anemia (phenotype) ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 2 Completed sickle cell anemia ClinicalTrials
ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 2 Completed hyperlipidemia ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 1 Terminated HIV infection ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 1 Withdrawn hypoxia ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 1 Completed serum lipopolysaccharide activity ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 1 Completed sarcopenia ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 1 Completed breast cancer ClinicalTrials
NOS1 TILARGININE Nitric oxide synthase inhibitor 1 Completed sickle cell anemia ClinicalTrials
ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

NOS1-Ser1417
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC -0.707
LUAD
LUSC
non_ccRCC
PDAC 0.707
UCEC
NOS1-Ser292
Cancer Intensity
BRCA
COAD 0.294
HGSC
ccRCC
GBM -0.602
HNSC
LUAD -1.22
LUSC 1.433
non_ccRCC
PDAC 0.094
UCEC
NOS1-Ser852
Cancer Intensity
BRCA
COAD 0.97
HGSC
ccRCC -0.624
GBM
HNSC -0.702
LUAD -1.331
LUSC 1.211
non_ccRCC -0.406
PDAC 0.882
UCEC
NOS1AP-Ser143
Cancer Intensity
BRCA 0.707
COAD
HGSC
ccRCC
GBM
HNSC
LUAD -0.707
LUSC
non_ccRCC
PDAC
UCEC
NOS1AP-Ser147
Cancer Intensity
BRCA 0.707
COAD
HGSC
ccRCC
GBM
HNSC
LUAD -0.707
LUSC
non_ccRCC
PDAC
UCEC
NOS1AP-Ser183
Cancer Intensity
BRCA
COAD
HGSC -0.707
ccRCC
GBM 0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
NOS1AP-Ser261
Cancer Intensity
BRCA 1.669
COAD 0.806
HGSC 1.226
ccRCC -0.532
GBM -1.331
HNSC -0.172
LUAD 0.013
LUSC -0.201
non_ccRCC -1.388
PDAC -0.091
UCEC
NOS1AP-Ser359
Cancer Intensity
BRCA
COAD
HGSC
ccRCC -0.707
GBM
HNSC
LUAD 0.707
LUSC
non_ccRCC
PDAC
UCEC
NOS1AP-Ser366
Cancer Intensity
BRCA 0.76
COAD -0.542
HGSC -1.96
ccRCC -0.353
GBM 0.255
HNSC 0.394
LUAD -0.48
LUSC -0.376
non_ccRCC 0.472
PDAC 1.829
UCEC
NOS1AP-Ser369
Cancer Intensity
BRCA 0.555
COAD -0.223
HGSC -2.21
ccRCC 0.045
GBM -0.438
HNSC
LUAD -0.047
LUSC 0.577
non_ccRCC 0.275
PDAC 1.467
UCEC
NOS1AP-Ser99
Cancer Intensity
BRCA
COAD -0.707
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC 0.707
non_ccRCC
PDAC
UCEC
NOS1AP-Thr259
Cancer Intensity
BRCA
COAD 1.464
HGSC 0.612
ccRCC -0.795
GBM
HNSC -0.519
LUAD -0.761
LUSC
non_ccRCC
PDAC
UCEC
NOS1AP-Thr95
Cancer Intensity
BRCA 0.956
COAD -1.039
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC 0.083
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: