| Id: | acc3779 |
| Group: | 1sens |
| Protein: | FOXO1 |
| Gene Symbol: | Foxo1 |
| Protein Id: | G3V7R4 |
| Protein Name: | FOXO1_RAT |
| PTM: | phosphorylation |
| Site: | Thr24 |
| Site Sequence: | EPLPRQRSCTWPLPRPEFNQS |
| Disease Category: | Systemic diseases |
| Disease: | Aging |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | CR reduces insulin |
| Drug Info: | CR is a drug that has the effect of reducing insulin. |
| Effect: | modulate |
| Effect Info: | "Calorie restriction (CR) inhibits FOXO1 phosphorylation through low insulin levels, thereby restricting NF-κB nuclear translocation during the aging process." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 17972158 |
| Sentence Index: | 17972158_9 |
| Sentence: | "We conclude that the phosphorylationation of FOXO1 regulates NF-kappaB nuclear translocation by activating PI3K/Akt during aging, which was suppressed by the hypoinsulinemic action of CR." |
Sequence & Structure:
MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEFNQSNSTTSSPAPSGSTAANPDATASLASASAVSTDFMSNLSLLEESEDFARAPGCVAVAAAAAASRGLCGDFQGPEAGCVHSAPPQPPPTGPLSQPPPVPPAAAGPLAGQPRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQEGPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGSMMQQTPCYSFAPPNTSLNSPSPNYAKYTYGQSSMSPVPQMPMQTLQDSKSSYGGLNQYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVLMGPNSVMPAYGSQAPHNKMMNPSSHTHPGHAQQTSSVNGRALPHVVNTMPHTSAMNRLTPVKTPLQVPLSHPMQMSALGNYSSVSSCNGYGRMGVLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
