| Id: | acc3804 |
| Group: | 1sens |
| Protein: | eNOS |
| Gene Symbol: | NOS3 |
| Protein Id: | Q8IVI9 |
| Protein Name: | NOSTN_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser1179 |
| Site Sequence: | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Cardiovascular Disease |
| Disease Subtype: | |
| Disease Cellline: | BAECs |
| Disease Info: | |
| Drug: | H2O2 |
| Drug Info: | "H2O2 is hydrogen peroxide, a common disinfectant and oxidizing agent." |
| Effect: | modulate |
| Effect Info: | "Long - term exposure to H?O? reduces the phosphorylation of eNOS Ser(1179), which may be the cause of eNOS dysfunction in cardiovascular diseases with chronic oxidative damage." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 18617528 |
| Sentence Index: | 18617528_15 |
| Sentence: | "Long term H(2)O(2) exposure decreased eNOS Ser(1179) phosphorylation, and this might account for the loss of eNOS function in cardiovascular diseases where chronic oxidative injury occurs." |
Sequence & Structure:
MRDPLTDCPYNKVYKNLKEFSQNGENFCKQVTSVLQQRANLEISYAKGLQKLASKLSKALQNTRKSCVSSAWAWASEGMKSTADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQSMTEKEKRKLLNKLTKSTEKLEKEDENYYQKNMAGYSTRLKWENTLENCYQSILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDIEKDIQAVMEETAILSTENKSEFLLTDYFEEDPNSAMDKERRKSLLKPKLLRLQRDIEKASKDKEGLERMLKTYSSTSSFSDAKSQKDTAALMDENNLKLDLLEANSYKLSSMLAELEQRPQPSHPCSNSIFRWREKEHTHSYVKISRPFLMKRLENIVSKASSGGQSNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKEGGWWFGSLNGKKGHFPAAYVEELPSNAGNTATKA
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
