Id: acc3810
Group: 1sens
Protein: AMPK
Gene Symbol: Prkaa2
Protein Id: Q09137
Protein Name: AAPK2_RAT
PTM: phosphorylation
Site: Thr172
Site Sequence: MMSDGEFLRTSCGSPNYAAPE
Disease Category: Endocrine and metabolic diseases
Disease: Hypothyroidism
Disease Subtype:
Disease Cellline:
Disease Info:
Drug: T3
Drug Info: "T3 is a thyroid hormone, also known as triiodothyronine, which plays a crucial role in regulating metabolism."
Effect: no effect
Effect Info: "In hypothyroid rats, T3 is involved in regulating muscle energy metabolism by activating the AMPK–ACC metabolic pathway."
Note: no effect
Score: 2.0
Pubmed(PMID): 18703632
Sentence Index:
Sentence:

Sequence & Structure:

MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSIATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPTGSFMDDMAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSVDSSTAENHSLSGSLTGSLTGSTLSSASPRLGSHTMDFFEMCASLITALAR

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 172 D Type 2 diabetes Phosphorylation 33848515

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: