| Id: | acc3812 |
| Group: | 1sens |
| Protein: | JNK |
| Gene Symbol: | Mapk8 |
| Protein Id: | P49185 |
| Protein Name: | MK08_RAT |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Digestive system diseases |
| Disease: | Pancreatitis |
| Disease Subtype: | caerulein-induced |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | PAR2-AP |
| Drug Info: | PAR2-AP is a drug that may have specific pharmacological effects and applications in relevant medical research or treatment fields. |
| Effect: | inhibit |
| Effect Info: | "By inducing the expression of MKPs and accelerating the dephosphorylation of ERK and JNK, the intra - pancreatic injury in acute pancreatitis can be alleviated." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 18755806 |
| Sentence Index: | 18755806_8 |
| Sentence: | Inhibition of ERK and JNK phosphorylation by the pretreatment with MAP/ERK kinase (MEK) or JNK inhibitors decreased caerulein-induced pancreatic damage that was similar to the effect induced by PAR2-AP. |
Sequence & Structure:
MSRSKRDNNFYSVEIADSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCLKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLGAAVINGSQHPVSSPSVNDMSSMSTDPTLASD
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| T | 183 | D | Alzheimer's disease | Phosphorylation | 23474850 |
| T | 183 | D | Short-term oestrogen deprivation | Phosphorylation | 23474850 |
| Y | 185 | D | Alzheimer's disease | Phosphorylation | 23474850 |
| Y | 185 | D | Short-term oestrogen deprivation | Phosphorylation | 23474850 |
| T | 183 | U | Alzheimer's disease | Phosphorylation | 23474850 |
| T | 183 | U | Short-term oestrogen deprivation | Phosphorylation | 23474850 |
| Y | 185 | U | Alzheimer's disease | Phosphorylation | 23474850 |
| Y | 185 | U | Short-term oestrogen deprivation | Phosphorylation | 23474850 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
