| Id: | acc3813 |
| Group: | 1sens |
| Protein: | ERK |
| Gene Symbol: | Mapk1 |
| Protein Id: | P21708 |
| Protein Name: | MK03_RAT |
| PTM: | nitration |
| Site: | Tyr |
| Site Sequence: | |
| Disease Category: | Digestive system diseases |
| Disease: | Gastric Mucosal Healing |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | rebamipid |
| Drug Info: | "Rebamipid is a drug that promotes mucosal protection and repair, often used in the treatment of gastric ulcers and gastritis." |
| Effect: | modulate |
| Effect Info: | Rebamipide improves the healing response after gastric mucosal injury by inhibiting the nitration modification of ERK. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 18787063 |
| Sentence Index: | 18787063_7 |
| Sentence: | "Administration of rebamipide, a gastroprotective drug that acts as an oxygen-derived free radical scavenger, significantly decreased LPO and nitrotyrosine as well as the nitration of ERK by peroxynitrite in PHT gastric mucosa, therefore normalizing ERK activation and restoring the gastric mucosal healing response to ethanol injury." |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEAP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
