| Id: | acc3816 |
| Group: | 1sens |
| Protein: | IkappaBalpha |
| Gene Symbol: | Nfkbia |
| Protein Id: | Q63746 |
| Protein Name: | IKBA_RAT |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Inflammatory |
| Disease Subtype: | hypertension |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Troglitazone |
| Drug Info: | Troglitazone is a drug that was once used to treat type 2 diabetes. It was later withdrawn from the market due to its potential to cause severe liver damage. |
| Effect: | modulate |
| Effect Info: | Troglitazone + IL-1β → ↑ Phosphorylation of IκBα → Release of NF-κB → ↑ Expression of COX-2 & iNOS |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 18827362 |
| Sentence Index: | 18827362_0 |
| Sentence: | Troglitazone increases IL-1beta induced cyclooxygenase-2 and inducible nitric oxide synthase expression via enhanced phosphorylationation of IkappaBalpha in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats. |
Sequence & Structure:
MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEDYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLGIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQTLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
