Id: | acc3821 |
Group: | 1sens |
Protein: | STAT1 |
Gene Symbol: | Stat1 |
Protein Id: | P42225 |
Protein Name: | STAT1_MOUSE |
PTM: | phosphorylation |
Site: | Tyr701 |
Site Sequence: | ELDDPKRTGYIKTELISVSEV |
Disease Category: | Cardiovascular and circulatory system diseases |
Disease: | Atherosclerosis |
Disease Subtype: | Aortic Atherosclerosis |
Disease Cellline: | |
Disease Info: | |
Drug: | Pravastatin? |
Drug Info: | Pravastatin is a medication used to lower cholesterol and reduce the risk of heart disease. It belongs to the class of drugs known as statins. |
Effect: | modulate |
Effect Info: | "Pravastatin inhibits the phosphorylation level of STAT1, attenuates IFN - γ signal transduction, and alleviates vascular inflammation and atherosclerotic lesions." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 19018808 |
Sentence Index: | 19018808_12 |
Sentence: | "5. These results suggest that the actions of pravastatin in attenuating the action of IFN-gamma and subsequently preventing aortic atherosclerosis may depend, at least in part, on modulation of STAT1 activity." |
Sequence & Structure:
MSQWFELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIYNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEQEIKTLEELQDEYDFKCKTSQNREGEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQTWFTIVAETLQQIRQQLKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKSRLLVKLQESNLLTKVKCHFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAELRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKNDLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEMSRIVGPEFDSMMSTV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.