Id: | acc3826 |
Group: | 1sens |
Protein: | ERK1 |
Gene Symbol: | Mapk3 |
Protein Id: | Q63844 |
Protein Name: | MK03_MOUSE |
PTM: | phosphorylation |
Site: | Tyr204 |
Site Sequence: | EHDHTGFLTEYVATRWYRAPE |
Disease Category: | Endocrine and metabolic diseases |
Disease: | Diabetes Mellitus |
Disease Subtype: | type 1 diabetic |
Disease Cellline: | |
Disease Info: | |
Drug: | Sphingosine-1-phosphate(S1P) + SEW2871 |
Drug Info: | Sphingosine-1-phosphate(S1P) is a bioactive lipid messenger involved in various cellular processes. | SEW2871 is a synthetic agonist of S1P receptors. |
Effect: | modulate |
Effect Info: | Co - culturing endothelial cells (EC) from diabetic NOD mice with S1P and its S1P(1) receptor - selective agonist SEW2871 significantly increased the expression of MKP - 3 and reduced the phosphorylation of ERK1/2. |
Note: | drug comb |
Score: | 4.0 |
Pubmed(PMID): | 19091959 |
Sentence Index: | 19091959_10 |
Sentence: | "Incubation of diabetic NOD EC with S1P and the S1P(1)-selective agonist SEW2871 significantly increased expression of MKP-3 and reduced ERK1/2 phosphorylation, while incubation with the S1P(1)/S1P(3) antagonist VPC23019 decreased the expression of MKP-3, both results supporting a role for S1P(1) in MKP-3 regulation." |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEGP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
T | 203 | U | Squamous cell carcinoma | Phosphorylation | 19934324 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.