| Id: | acc3831 |
| Group: | 1sens |
| Protein: | P38 |
| Gene Symbol: | Mapk14 |
| Protein Id: | P47811 |
| Protein Name: | MK14_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr180 |
| Site Sequence: | LARHTDDEMTGYVATRWYRAP |
| Disease Category: | Nervous system diseases |
| Disease: | Neurotoxic |
| Disease Subtype: | |
| Disease Cellline: | BV-2 |
| Disease Info: | |
| Drug: | tBHQ |
| Drug Info: | tBHQ is a synthetic antioxidant commonly used in the food industry to prevent lipid oxidation. |
| Effect: | modulate |
| Effect Info: | The antioxidant tBHQ can significantly inhibit lipopolysaccharide (LPS)-induced p38 mitogen-activated protein kinase (MAPK) phosphorylation and alleviate neurotoxicity. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 19174151 |
| Sentence Index: | 19174151_3 |
| Sentence: | Pretreatment of BV-2 cells with tBHQ suppressed LPS-induced phosphorylation of p38 required for overproduction of neurotoxic mediators. |
Sequence & Structure:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
