Id: | acc3836 |
Group: | 1sens |
Protein: | AMPK |
Gene Symbol: | Prkaa2 |
Protein Id: | Q09137 |
Protein Name: | AAPK2_RAT |
PTM: | phosphorylation |
Site: | Thr172 |
Site Sequence: | MMSDGEFLRTSCGSPNYAAPE |
Disease Category: | Cardiovascular and circulatory system diseases |
Disease: | Left Ventricular Hypertrophy |
Disease Subtype: | |
Disease Cellline: | |
Disease Info: | |
Drug: | Resveratrol |
Drug Info: | "Resveratrol is a polyphenolic compound found in various plants, known for its potential antioxidant and anti - inflammatory properties." |
Effect: | modulate |
Effect Info: | "Resveratrol increases the phosphorylation levels of LKB1 and AMPK, while reducing the phosphorylation levels of mTOR and p70S6K, and improves left ventricular hypertrophy in SHR rats." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 19289642 |
Sentence Index: | 19289642_9 |
Sentence: | "Furthermore, administration of resveratrol to spontaneously hypertensive rats results in increased AMPK phosphorylationation and activity and reduced left ventricular hypertrophy." |
Sequence & Structure:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSIATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPTGSFMDDMAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSVDSSTAENHSLSGSLTGSLTGSTLSSASPRLGSHTMDFFEMCASLITALAR
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
T | 172 | D | Type 2 diabetes | Phosphorylation | 33848515 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.