| Id: | acc3854 |
| Group: | 1sens |
| Protein: | MKP-1 |
| Gene Symbol: | Dusp1 |
| Protein Id: | P28563 |
| Protein Name: | DUS1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser539 |
| Site Sequence: | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
| Disease Category: | Infectious diseases |
| Disease: | Endotoxic Shock |
| Disease Subtype: | Endotoxic Shock |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | U0126 |
| Drug Info: | "U0126 is a drug, but specific details about it are not provided." |
| Effect: | modulate |
| Effect Info: | "The ERK inhibitor U0126 blocked Gln-induced MKP-1 phosphorylation and protein induction, as well as the protective activity of Gln against endotoxin shock." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 19494320 |
| Sentence Index: | 19494320_8 |
| Sentence: | "The ERK inhibitor U0126 blocked Gln-induced MKP-1 phosphorylation and protein induction, as well as Gln's protective activity against endotoxic shock." |
Sequence & Structure:
MVMEVGILDAGGLRALLREGAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSASLDGAKRDGTLALAAGALCREARSTQVFFLQGGYEAFSASCPELCSKQSTPTGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILSFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKDAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHPTNSALNYLKSPITTSPSC
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
