| Id: | acc3858 |
| Group: | 1sens |
| Protein: | FOXO1 |
| Gene Symbol: | Foxo1 |
| Protein Id: | Q9R1E0 |
| Protein Name: | FOXO1_MOUSE |
| PTM: | acetylation |
| Site: | Lys |
| Site Sequence: | |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Alcoholic Fatty Liver |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Rosiglitazone |
| Drug Info: | Rosiglitazone is a thiazolidinedione antidiabetic drug that works by improving insulin sensitivity. |
| Effect: | modulate |
| Effect Info: | Rosiglitazone eliminated the excessive acetylation of PGC - 1α and FoxO1 (two known SIRT1 targets) induced by ethanol. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 20007851 |
| Sentence Index: | 20007851_3 |
| Sentence: | "The aim of the present study was to test the ability of rosiglitazone, a known PPAR-gamma agonist, to reverse the inhibitory effects of ethanol on adiponectin expression and its hepatic signaling, and to attenuate alcoholic liver steatosis in mice." |
Sequence & Structure:
MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEFNQSNSTTSSPAPSGGAAANPDAAASLASASAVSTDFMSNLSLLEESEDFARAPGCVAVAAAAAASRGLCGDFQGPEAGCVHPAPPQPPPTGPLSQPPPVPPSAAAAAGPLAGQPRKTSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRGRAAKKKASLQSGQEGPGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGDGDVHSLVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGSMMQQTPCYSFAPPNTSLNSPSPNYSKYTYGQSSMSPLPQMPMQTLQDSKSSYGGLNQYNCAPGLLKELLTSDSPPHNDIMSPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQASHNKMMNPSSHTHPGHAQQTASVNGRTLPHVVNTMPHTSAMNRLTPVKTPLQVPLSHPMQMSALGSYSSVSSCNGYGRMGVLHQEKLPSDLDGMFIERLDCDMESIIRNDLMDGDTLDFNFDNVLPNQSFPHSVKTTTHSWVSG
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
